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stroma derived factor 1 sdf1  (R&D Systems)


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    R&D Systems stroma derived factor 1 sdf1
    Sections from paired primary prostate tumors and bone metastases immune stained for ETS-related gene (ERG) ( a , h ), prostate specific antigen (PSA) ( b ), the marker for proliferation Ki67 ( c ), androgen receptor (AR) ( d ), smooth muscle actin (SMA) ( e ), stroma derived factor 1 <t>(SDF1)</t> ( f ), and platelet-derived growth factor receptor β (PDGFRB) ( g ), all seen at the same magnification (see scalebar in ( a )). ( a ) ERG positive tumor cells in a primary tumor and in the paired metastasis. ( b ) Moderate (left side) to high (right side with glands) PSA staining in a primary tumor. Moderate PSA staining and glandular differentiation was seen in the metastasis (classified as MetA). ( c ) Sections with relatively high Ki67 labeling in epithelium and stroma in a primary tumor and in the paired bone metastasis. ( d ) AR positive epithelial and stroma cells were seen in the primary tumor. In the metastasis (classified as MetA), a nest of AR positive tumor cells was growing in a bone marrow space and a few AR positive cells are seen on the bone surface. ( e ) Numerous SMA positive smooth muscle cells are seen in the primary tumor, whereas only few cells were SMA positive in the paired bone metastasis (here only in blood vessel walls). This metastasis, lacking bone structures, was classified as MetB. ( f ) SDF-1 positive cells were seen in the stroma in the primary tumor, mainly in blood vessel walls. Such cells were also seen in the bone metastasis stroma. ( g ) PDGFRB positive stroma cells, mainly in blood vessel walls and in fibroblasts, were seen in the primary tumor stroma and in the paired metastasis (classified as MetB). ( h ) ERG positive endothelial cell nuclei were seen in the primary tumor and in its bone metastasis. Note that several tumor cells are lying close to endothelial cells. In this case, the tumor cells were ERG negative. This metastasis was classified as Ki67 high/PSA low but with unknown MetA-C status. Blood vessels with ERG positive endothelial cells and walls positive for SMA, PDGFR-beta, and SDF-1 were a dominant component of the bone metastasis stroma.
    Stroma Derived Factor 1 Sdf1, supplied by R&D Systems, used in various techniques. Bioz Stars score: 95/100, based on 257 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/stroma+derived+factor+1+sdf1/Human%2FMouse+CXCL12%2FSDF-1+Antibody/pmc09659192-121-0-7
    Average 95 stars, based on 257 article reviews
    stroma derived factor 1 sdf1 - by Bioz Stars, 2026-09
    95/100 stars

    Images

    1) Product Images from "Epithelial and Stromal Characteristics of Primary Tumors Predict the Bone Metastatic Subtype of Prostate Cancer and Patient Survival after Androgen-Deprivation Therapy"

    Article Title: Epithelial and Stromal Characteristics of Primary Tumors Predict the Bone Metastatic Subtype of Prostate Cancer and Patient Survival after Androgen-Deprivation Therapy

    Journal: Cancers

    doi: 10.3390/cancers14215195

    Sections from paired primary prostate tumors and bone metastases immune stained for ETS-related gene (ERG) ( a , h ), prostate specific antigen (PSA) ( b ), the marker for proliferation Ki67 ( c ), androgen receptor (AR) ( d ), smooth muscle actin (SMA) ( e ), stroma derived factor 1 (SDF1) ( f ), and platelet-derived growth factor receptor β (PDGFRB) ( g ), all seen at the same magnification (see scalebar in ( a )). ( a ) ERG positive tumor cells in a primary tumor and in the paired metastasis. ( b ) Moderate (left side) to high (right side with glands) PSA staining in a primary tumor. Moderate PSA staining and glandular differentiation was seen in the metastasis (classified as MetA). ( c ) Sections with relatively high Ki67 labeling in epithelium and stroma in a primary tumor and in the paired bone metastasis. ( d ) AR positive epithelial and stroma cells were seen in the primary tumor. In the metastasis (classified as MetA), a nest of AR positive tumor cells was growing in a bone marrow space and a few AR positive cells are seen on the bone surface. ( e ) Numerous SMA positive smooth muscle cells are seen in the primary tumor, whereas only few cells were SMA positive in the paired bone metastasis (here only in blood vessel walls). This metastasis, lacking bone structures, was classified as MetB. ( f ) SDF-1 positive cells were seen in the stroma in the primary tumor, mainly in blood vessel walls. Such cells were also seen in the bone metastasis stroma. ( g ) PDGFRB positive stroma cells, mainly in blood vessel walls and in fibroblasts, were seen in the primary tumor stroma and in the paired metastasis (classified as MetB). ( h ) ERG positive endothelial cell nuclei were seen in the primary tumor and in its bone metastasis. Note that several tumor cells are lying close to endothelial cells. In this case, the tumor cells were ERG negative. This metastasis was classified as Ki67 high/PSA low but with unknown MetA-C status. Blood vessels with ERG positive endothelial cells and walls positive for SMA, PDGFR-beta, and SDF-1 were a dominant component of the bone metastasis stroma.
    Figure Legend Snippet: Sections from paired primary prostate tumors and bone metastases immune stained for ETS-related gene (ERG) ( a , h ), prostate specific antigen (PSA) ( b ), the marker for proliferation Ki67 ( c ), androgen receptor (AR) ( d ), smooth muscle actin (SMA) ( e ), stroma derived factor 1 (SDF1) ( f ), and platelet-derived growth factor receptor β (PDGFRB) ( g ), all seen at the same magnification (see scalebar in ( a )). ( a ) ERG positive tumor cells in a primary tumor and in the paired metastasis. ( b ) Moderate (left side) to high (right side with glands) PSA staining in a primary tumor. Moderate PSA staining and glandular differentiation was seen in the metastasis (classified as MetA). ( c ) Sections with relatively high Ki67 labeling in epithelium and stroma in a primary tumor and in the paired bone metastasis. ( d ) AR positive epithelial and stroma cells were seen in the primary tumor. In the metastasis (classified as MetA), a nest of AR positive tumor cells was growing in a bone marrow space and a few AR positive cells are seen on the bone surface. ( e ) Numerous SMA positive smooth muscle cells are seen in the primary tumor, whereas only few cells were SMA positive in the paired bone metastasis (here only in blood vessel walls). This metastasis, lacking bone structures, was classified as MetB. ( f ) SDF-1 positive cells were seen in the stroma in the primary tumor, mainly in blood vessel walls. Such cells were also seen in the bone metastasis stroma. ( g ) PDGFRB positive stroma cells, mainly in blood vessel walls and in fibroblasts, were seen in the primary tumor stroma and in the paired metastasis (classified as MetB). ( h ) ERG positive endothelial cell nuclei were seen in the primary tumor and in its bone metastasis. Note that several tumor cells are lying close to endothelial cells. In this case, the tumor cells were ERG negative. This metastasis was classified as Ki67 high/PSA low but with unknown MetA-C status. Blood vessels with ERG positive endothelial cells and walls positive for SMA, PDGFR-beta, and SDF-1 were a dominant component of the bone metastasis stroma.

    Techniques Used: Staining, Marker, Derivative Assay, Labeling

    Related Articles

    Derivative Assay:

    Article Title: Epithelial and Stromal Characteristics of Primary Tumors Predict the Bone Metastatic Subtype of Prostate Cancer and Patient Survival after Androgen-Deprivation Therapy
    Article Snippet: Sections were also stained for smooth muscle actin (SMA) (M0851/clone 1A4, DAKO Agilent, Santa Clara, CA, US, 1:150) using the automated BenchMark ULTRA system (Roche Diagnostics, Indianapolis, IN, US) with Cell Conditioning 1 (CC1) as antigen retrieval buffer and developed using the Ultraview Universal DAB Detection kit (Ventata Systems, Tuscon, Arizona, US). .. Stroma derived factor 1 (SDF1) (MAB350/clone 79018, R&D Systems, Minneapolis, MN, US) 1:50 overnight) was stained manually using Tris-EDTA pH9 as antigen retrieval and developed with DAB (Mach3Mouse HRP-Polymer Detection, M3M530, Biocare Medical, Pacheco, CA, US). ..

    Staining:

    Article Title: Epithelial and Stromal Characteristics of Primary Tumors Predict the Bone Metastatic Subtype of Prostate Cancer and Patient Survival after Androgen-Deprivation Therapy
    Article Snippet: Sections were also stained for smooth muscle actin (SMA) (M0851/clone 1A4, DAKO Agilent, Santa Clara, CA, US, 1:150) using the automated BenchMark ULTRA system (Roche Diagnostics, Indianapolis, IN, US) with Cell Conditioning 1 (CC1) as antigen retrieval buffer and developed using the Ultraview Universal DAB Detection kit (Ventata Systems, Tuscon, Arizona, US). .. Stroma derived factor 1 (SDF1) (MAB350/clone 79018, R&D Systems, Minneapolis, MN, US) 1:50 overnight) was stained manually using Tris-EDTA pH9 as antigen retrieval and developed with DAB (Mach3Mouse HRP-Polymer Detection, M3M530, Biocare Medical, Pacheco, CA, US). ..



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    stroma derived factor 1 sdf1  (R&D Systems)
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    Sections from paired primary prostate tumors and bone metastases immune stained for ETS-related gene (ERG) ( a , h ), prostate specific antigen (PSA) ( b ), the marker for proliferation Ki67 ( c ), androgen receptor (AR) ( d ), smooth muscle actin (SMA) ( e ), stroma derived factor 1 <t>(SDF1)</t> ( f ), and platelet-derived growth factor receptor β (PDGFRB) ( g ), all seen at the same magnification (see scalebar in ( a )). ( a ) ERG positive tumor cells in a primary tumor and in the paired metastasis. ( b ) Moderate (left side) to high (right side with glands) PSA staining in a primary tumor. Moderate PSA staining and glandular differentiation was seen in the metastasis (classified as MetA). ( c ) Sections with relatively high Ki67 labeling in epithelium and stroma in a primary tumor and in the paired bone metastasis. ( d ) AR positive epithelial and stroma cells were seen in the primary tumor. In the metastasis (classified as MetA), a nest of AR positive tumor cells was growing in a bone marrow space and a few AR positive cells are seen on the bone surface. ( e ) Numerous SMA positive smooth muscle cells are seen in the primary tumor, whereas only few cells were SMA positive in the paired bone metastasis (here only in blood vessel walls). This metastasis, lacking bone structures, was classified as MetB. ( f ) SDF-1 positive cells were seen in the stroma in the primary tumor, mainly in blood vessel walls. Such cells were also seen in the bone metastasis stroma. ( g ) PDGFRB positive stroma cells, mainly in blood vessel walls and in fibroblasts, were seen in the primary tumor stroma and in the paired metastasis (classified as MetB). ( h ) ERG positive endothelial cell nuclei were seen in the primary tumor and in its bone metastasis. Note that several tumor cells are lying close to endothelial cells. In this case, the tumor cells were ERG negative. This metastasis was classified as Ki67 high/PSA low but with unknown MetA-C status. Blood vessels with ERG positive endothelial cells and walls positive for SMA, PDGFR-beta, and SDF-1 were a dominant component of the bone metastasis stroma.
    Stroma Derived Factor 1 Sdf1, supplied by R&D Systems, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/stroma+derived+factor+1+sdf1/Human%2FMouse+CXCL12%2FSDF-1+Antibody/pmc09659192-121-0-7
    Average 95 stars, based on 1 article reviews
    stroma derived factor 1 sdf1 - by Bioz Stars, 2026-09
    95/100 stars
    		  Buy from Supplier
    stroma-cell derived factor-1 (sdf1-α)  (PeproTech)
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    Sections from paired primary prostate tumors and bone metastases immune stained for ETS-related gene (ERG) ( a , h ), prostate specific antigen (PSA) ( b ), the marker for proliferation Ki67 ( c ), androgen receptor (AR) ( d ), smooth muscle actin (SMA) ( e ), stroma derived factor 1 <t>(SDF1)</t> ( f ), and platelet-derived growth factor receptor β (PDGFRB) ( g ), all seen at the same magnification (see scalebar in ( a )). ( a ) ERG positive tumor cells in a primary tumor and in the paired metastasis. ( b ) Moderate (left side) to high (right side with glands) PSA staining in a primary tumor. Moderate PSA staining and glandular differentiation was seen in the metastasis (classified as MetA). ( c ) Sections with relatively high Ki67 labeling in epithelium and stroma in a primary tumor and in the paired bone metastasis. ( d ) AR positive epithelial and stroma cells were seen in the primary tumor. In the metastasis (classified as MetA), a nest of AR positive tumor cells was growing in a bone marrow space and a few AR positive cells are seen on the bone surface. ( e ) Numerous SMA positive smooth muscle cells are seen in the primary tumor, whereas only few cells were SMA positive in the paired bone metastasis (here only in blood vessel walls). This metastasis, lacking bone structures, was classified as MetB. ( f ) SDF-1 positive cells were seen in the stroma in the primary tumor, mainly in blood vessel walls. Such cells were also seen in the bone metastasis stroma. ( g ) PDGFRB positive stroma cells, mainly in blood vessel walls and in fibroblasts, were seen in the primary tumor stroma and in the paired metastasis (classified as MetB). ( h ) ERG positive endothelial cell nuclei were seen in the primary tumor and in its bone metastasis. Note that several tumor cells are lying close to endothelial cells. In this case, the tumor cells were ERG negative. This metastasis was classified as Ki67 high/PSA low but with unknown MetA-C status. Blood vessels with ERG positive endothelial cells and walls positive for SMA, PDGFR-beta, and SDF-1 were a dominant component of the bone metastasis stroma.
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    https://www.bioz.com/product/stroma+derived+factor+1+sdf1/sdf+1+chemokine/pmc07349827-217-6-10
    Average 90 stars, based on 1 article reviews
    stroma-cell derived factor-1 (sdf1-α) - by Bioz Stars, 2026-09
    90/100 stars
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    Image Search Results


    Sections from paired primary prostate tumors and bone metastases immune stained for ETS-related gene (ERG) ( a , h ), prostate specific antigen (PSA) ( b ), the marker for proliferation Ki67 ( c ), androgen receptor (AR) ( d ), smooth muscle actin (SMA) ( e ), stroma derived factor 1 (SDF1) ( f ), and platelet-derived growth factor receptor β (PDGFRB) ( g ), all seen at the same magnification (see scalebar in ( a )). ( a ) ERG positive tumor cells in a primary tumor and in the paired metastasis. ( b ) Moderate (left side) to high (right side with glands) PSA staining in a primary tumor. Moderate PSA staining and glandular differentiation was seen in the metastasis (classified as MetA). ( c ) Sections with relatively high Ki67 labeling in epithelium and stroma in a primary tumor and in the paired bone metastasis. ( d ) AR positive epithelial and stroma cells were seen in the primary tumor. In the metastasis (classified as MetA), a nest of AR positive tumor cells was growing in a bone marrow space and a few AR positive cells are seen on the bone surface. ( e ) Numerous SMA positive smooth muscle cells are seen in the primary tumor, whereas only few cells were SMA positive in the paired bone metastasis (here only in blood vessel walls). This metastasis, lacking bone structures, was classified as MetB. ( f ) SDF-1 positive cells were seen in the stroma in the primary tumor, mainly in blood vessel walls. Such cells were also seen in the bone metastasis stroma. ( g ) PDGFRB positive stroma cells, mainly in blood vessel walls and in fibroblasts, were seen in the primary tumor stroma and in the paired metastasis (classified as MetB). ( h ) ERG positive endothelial cell nuclei were seen in the primary tumor and in its bone metastasis. Note that several tumor cells are lying close to endothelial cells. In this case, the tumor cells were ERG negative. This metastasis was classified as Ki67 high/PSA low but with unknown MetA-C status. Blood vessels with ERG positive endothelial cells and walls positive for SMA, PDGFR-beta, and SDF-1 were a dominant component of the bone metastasis stroma.

    Journal: Cancers

    Article Title: Epithelial and Stromal Characteristics of Primary Tumors Predict the Bone Metastatic Subtype of Prostate Cancer and Patient Survival after Androgen-Deprivation Therapy

    doi: 10.3390/cancers14215195

    Figure Lengend Snippet: Sections from paired primary prostate tumors and bone metastases immune stained for ETS-related gene (ERG) ( a , h ), prostate specific antigen (PSA) ( b ), the marker for proliferation Ki67 ( c ), androgen receptor (AR) ( d ), smooth muscle actin (SMA) ( e ), stroma derived factor 1 (SDF1) ( f ), and platelet-derived growth factor receptor β (PDGFRB) ( g ), all seen at the same magnification (see scalebar in ( a )). ( a ) ERG positive tumor cells in a primary tumor and in the paired metastasis. ( b ) Moderate (left side) to high (right side with glands) PSA staining in a primary tumor. Moderate PSA staining and glandular differentiation was seen in the metastasis (classified as MetA). ( c ) Sections with relatively high Ki67 labeling in epithelium and stroma in a primary tumor and in the paired bone metastasis. ( d ) AR positive epithelial and stroma cells were seen in the primary tumor. In the metastasis (classified as MetA), a nest of AR positive tumor cells was growing in a bone marrow space and a few AR positive cells are seen on the bone surface. ( e ) Numerous SMA positive smooth muscle cells are seen in the primary tumor, whereas only few cells were SMA positive in the paired bone metastasis (here only in blood vessel walls). This metastasis, lacking bone structures, was classified as MetB. ( f ) SDF-1 positive cells were seen in the stroma in the primary tumor, mainly in blood vessel walls. Such cells were also seen in the bone metastasis stroma. ( g ) PDGFRB positive stroma cells, mainly in blood vessel walls and in fibroblasts, were seen in the primary tumor stroma and in the paired metastasis (classified as MetB). ( h ) ERG positive endothelial cell nuclei were seen in the primary tumor and in its bone metastasis. Note that several tumor cells are lying close to endothelial cells. In this case, the tumor cells were ERG negative. This metastasis was classified as Ki67 high/PSA low but with unknown MetA-C status. Blood vessels with ERG positive endothelial cells and walls positive for SMA, PDGFR-beta, and SDF-1 were a dominant component of the bone metastasis stroma.

    Article Snippet: Stroma derived factor 1 (SDF1) (MAB350/clone 79018, R&D Systems, Minneapolis, MN, US) 1:50 overnight) was stained manually using Tris-EDTA pH9 as antigen retrieval and developed with DAB (Mach3Mouse HRP-Polymer Detection, M3M530, Biocare Medical, Pacheco, CA, US).

    Techniques: Staining, Marker, Derivative Assay, Labeling